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KMID : 0378019910340010099
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New Medical Journal
1991 Volume.34 No. 1 p.99 ~ p.104
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Clinical Study of Oral Broncho-Vaxom in the Treatment of Chronic Bronchitis or Recurrent Acute Respiratory Infections
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Abstract
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Recognition that immunodeficiency is an internal risk factor in chronic bronchitis has led to increasing use of immunostimulants, i.e., substances that strengthen the body´s natural immune defense mechanisms, in the prevention and treatment of chronic bronchitis and of other infections of the respiratory passages. One such substance is the orally administered lyophilized bacterial lysate, Broncho-Vaxom.
We gave Broncho-Vaxom over a 4-month observation period to patients with chronic bronchitis or recurrent acute respiratory infections. We had started 22 patients, but two patients were lost of follow up and one patient was dropped because of pneumonia after one month of Broncho-Vaxom treatment.
Improvement in symptoms such as dyspnea, cough, expectoration, fever and wheeze, and abnormal physical signs on auscultation was noted. And peak flow rate had an increasing tendency.
Comparison with the corresponding 4-month autumn-winter period of the previous year showed the mean frequency of acute attacks to have a tendency of reduction in the Broncho-Vaxom group and the mean duration of the exacerbations to have a tendency of decrease.
Broncho-Vaxom was well tolerated and side effects was negligible.
We concluded that the effects of Broncho-Vaxom, whether administered curatively or preventively, showed the superiority of this immunobiotherapeutic drug over the conventional symptomatic measures.
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